EFFECTS OF ANTIARRHYTHMIC DRUGS ON HERG GATING IN HUMAN-INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES FROM A PATIENT WITH SHORT QT SYNDROME TYPE 1

Aims: The short QT syndrome type 1 (SQT1) is linked to hERG channel mutations (e.g., N588K).Drug effects on hERG channel gating kinetics in SQT1-cells have not been investigated.Methods: This study used hiPSC-CMs of a healthy donor and a SQT1-patient carrying the N588K mutation and patch clamp to examine the drug effects on hERG channel Knife Honin

Intentional islanding is a corrective procedure that aims to protect the stability of the power system during an emergency, by dividing the grid into several partitions and isolating the Hair Colour Retouch elements that would cause cascading failures.This paper proposes a deep learning method to solve the problem of intentional islanding in an end

With growing interest in commercial projects involving industrial volume CO2 sequestration, a concern about proper containment and control over the gas plume becomes particularly prominent.In this study, we explore the potential of using a typical coastal geopressured hot saline aquifer for two commercial purposes.The first purpose is to harvest ge

This study provides a novel methodology for the natural frequency estimation of the jet engine turbine blade by using the dimension check.This paper presents a summarization of the ongoing research devoted to the method for the turbine blade natural frequency estimation.The main target of the research presented in the paper is to develop a novel me

The method of machining negative pressure angle spiral clutches with disc milling cutter and gear milling machine is studied.The mathematical model is established according to the characteristics of spiral clutches firstly, and the coordinate transformation relationship from the cutting tool chart system to workpiece system, the tooth surface point